Musculoskeletal Radiology involves diagnostic imaging and image-guided procedures of the musculoskeletal system. Nuclear medicine, MRI, and CT are highly sensitive for detecting bone disease when x-rays are negative. MRI, CT and US are ideal modalities for detecting internal derangement of muscles, tendons, and ligaments. Arthrographic or intravenous contrast improves resolution and sensitivity of pathology on XR-fluoroscopy, CT, or MRI. Image guided biopsies and aspirations can be performed on bone with CT and on soft tissue with ultrasound. Fluoroscopy and US can provide biomechanical and functional information during injection and patient movement.